绝经后冠心病患者的骨密度及其相关因素分析

Bone Mineral Bensity in Postmenopause Female Patients With Coronary Heart Disease and Its Related Factors

目的 :探讨绝经后女性冠心病患者骨密度雌二醇 (E2 )变化及其相关因素。 方法 :研究了 60例绝经后女性冠心病患者 (冠心病组 )Ward’s三角的骨密度 ,雌激素雌二醇及血脂 ,同时以 60例绝经后女性健康人 (对照组 )作对照。 结果 :冠心病组骨密度较对照组降低 (P <0 0 1)。冠心病组中合并骨质疏松的比例高达 40 %。冠心病组雌二醇较对照组雌二醇降低 (P <0 0 1)。绝经后冠心病患者随着病程增加骨密度降低 ,呈显著负相关 (r=-0 93 ,P <0 0 1)。多因素逐步回归分析提示 ,骨密度与雌二醇呈正相关 (r=0 686,P <0 0 1) ,与甘油三酯 (TG)呈负相关 (r=-5 51,P <0 0 1)。 结论 :绝经后女性冠心病患者随病程延长其骨密度趋于降低 。

Objective: To investigate the change of b one mineral density(BMD) in postmenopause female patients with coro nary heart disease (CHD). Methods: One hundred and twenty postmenop ause females were divided into CHD grou p (n=60) and non CHD control gro up (n=60). BMD of Ward's triangle, plasma e strogen 2 and blood lipids were analyzed. Results: Compared with BMD of controls (0 622±0 083 g/cm 2), BMD of CHD patients(0 431±0 127 g/cm 2) were obv iously dec reased (p<0 01). Osteoporosis w as found in 40% of CHD patients. Meanwhile, E 2 level i n CHD group (53 91±19 03 pmol/L) was significantly lower than in contr ol gr oup (80 10±19 90 pmol/L,p<0 01). BMD in CHD group was negatively correlated w ith CHD severity(p<0 01). Multi ple factor regression analysis showed that plas ma E 2 and trigly ceride concentrations were independently r elated to BMD. Conclusion: BMD in postmenopause females with CHD was decreased with prolonged C HD course. Decreased E 2 and increased trig lycetide may be risk factor s for osteoporosis and coronary heart disea se in postmenopause females.