卡维地洛与比索洛尔对慢性心力衰竭长期疗效比较

Comparision of Long-Term Effects of Bisoprololvs Carvedilol for Heart Failure

目的 :观察 2种 β受体阻滞剂 [卡维地洛 (carvediol)及比索洛尔 (bisoprolol) ]对慢性心力衰竭 (心衰 )的长期疗效。 方法 :慢性心衰患者 97例 ,随机分为卡维地洛组 (n =3 2 ) ,比索洛尔组 (n =3 1)及对照组 (n =3 4 ) ,随访 6个月。观察心衰症状及心功能指标。 结果 :①卡维地洛组及比索洛尔组用药后心衰症状明显改善 (P <0 0 5) ,但两组间无显著差异。②卡维地洛组及比索洛尔组用药后左心室射血分数明显增加 (P <0 0 5) ,左心室舒张末期内径减小 (P <0 0 5) ,但两组间比较无显著差异。③用药后卡维地洛组较对照组血压下降明显 (P <0 0 5) ,而比索洛尔组较对照组心率下降明显 (P <0 0 5)。 结论 :卡维地洛及比索洛尔均能明显改善心功能 ,提高生活质量 。

Objective:The aim of this study was to assess the long term effe cts of bisoprolol and carvedilol in patients with chronic heart failure. Methods:Ninety seven patients with heart failure were randomized to bis oprolol or carvedilol or placebo. The pationts were follo wed up for 6 months.After 6 months of tr eatment both bisoprolol and carvedilol o ffered hemodynamic and clinical benefits in the patients with heart failure. Results:①There was great improvement of cardiac performance in both bisopr olol and carvedilol (p<0.05),but ther e was no significant differen in two groups. ②Both bisoprolol and carvedilol significantly increased left ventricular eject ion fraction (p<0 05) and decreased Left ventricular end diastolic dimension(p<0 05),but there was no significant difference in between groups .③Carvedilol decreased more significantl y artery pressure than placebo(p<0 05).Bisoprolol significa ntly reduced heart rate compared with pl acebo(p<0 05). Conclusions:The present study demonstrates that during long term therapy, both bisoprolol and carvedilol produced similar effects in improving he art function and quality of life in heart failure patients,but there was no significant difference between the two groups.