摘要
目的 :观察卡维地洛对急性心肌梗死患者血清Ⅲ型前胶原氨基端肽 (PⅢNP)水平及左心功能的影响。 方法 :将 80例急性心肌梗死患者随机分为常规治疗组 (40例 )和卡维地洛组 (40例 ) ,采用放射性免疫法测定血清PⅢNP及血浆内皮素的含量 ,采用彩色Doppler超声心动图仪测量左心室舒张功能和收缩功能参数。另选 3 0例体检健康者为对照组。 结果 :血清PⅢNP水平 :治疗后 1、 3、 4、 8周末常规治疗组和卡维地洛组与同组发病第 2天比较均升高 ,有显著性差异 (P <0 0 5或P <0 0 1) ;常规治疗组和卡维地洛组组间比较治疗后 1、 3、 8周亦有显著性差异 (P <0 0 5)。血浆内皮素水平、左心室射血分数和二尖瓣血流舒张早期流速 /心房收缩流速 :发病第 2天常规治疗组和卡维地洛组较对照组降低 ,有显著性差异 (P <0 0 1) ;常规治疗组和卡维地洛组组间比较治疗后 4周末亦有明显差异 (P <0 0 5或P<0 0 1)。治疗期间心脏事件发生率卡维地洛组明显低于常规治疗组 (P <0 0 5)。 结论 :卡维地洛能降低血清PⅢNP水平 。
Objective:To observe the effect of car vedilol on the elevels of serum aminoter mina l propeptide of type Ⅲ procollage (P ⅢNP) and left ventricular function in patients with ac ute myocar dial infarction(AMI). Method:A total of 80 patients with AMI w ere recruited in the study.Forty patien ts were randomized to conventional treat ment group,and the other 40 to carvedilo l treatment group.The serum PⅢNP and pla sma endothelin(ET) were measure d by specific radioimmunoassay. Color Do ppler echocardiography was performed to determine left ventricular diastolic fun ction(VE/VA) and left ventricul ar ejection fraction(LVEF). Results:After AMI,serum PⅢNP and ET we re significantly increased while VE/VA a nd LVEF obviously decreased.In compariso n with conventional treatment group,the increased serum PⅢNP and ET were signifi cantly reduced,while the decreased VE/VA and LVEF were elevated. Conlusion:Carvedilol can decrease the serum PⅢNP and improve left ventricular function.
出处
《中国循环杂志》
CSCD
北大核心
2003年第5期333-336,共4页
Chinese Circulation Journal
