转移性骨肿瘤的动脉导管化疗

Transcatheter Arterial Infusion-chemotherapy of Bone Metastases

目的 探讨血管内介入治疗对转移性骨肿瘤的治疗效果。资料与方法 一侧股动脉穿刺插管至相应的靶动脉并行血管造影 ,明确骨转移灶供血来源 ,对原发灶及转移灶分别行动脉内灌注化疗。间隔 2 5天～ 1个月复查X线片、血管造影再次介入治疗。结果 本组 2 0例共行 5 6次介入治疗。治疗后局部疼痛减轻 ,软组织肿块消失 ,临床症状明显改善。成骨性转移灶密度变淡或完全消失 ,溶骨性转移灶逐渐出现骨增生修复 ,肿瘤范围缩小 ,供血动脉变细 ,血管减少。无严重并发症发生。结论 血管内介入治疗对转移性骨肿瘤具有十分重要的治疗价值。

Objective To evaluate the curative effects of transcatheter arterial infusion chemotherapy of skeletal metastases. Materials and Methods Angiography of targeted arteries was performed after catheterization via one femoral artery. Once the tumor feeding arteries were identified arterial infusion chemotherapies at the primary lesion and the metastasic lesions were carried out separately. With an interval of 25 days to 1 month X ray plain films were taken and intra arterial chemotherapy was repeated with angiography. Results 20 patients underwent treatment at 56 times. Local pain and other clinical symptoms were relived markedly and soft tissue mass was disappeared on images. The density of osteogenic metastases became subtler or disappeared completely. The osteolytic metastases were repaired gradually by hyperplasia. The tumor became smaller with fewer and thinner feeding arteries. No severe complication was found. Conclusion Intra arterial intervention therapy has great value in treatment of skeletal metastases.