宫颈癌患者沙眼衣原体感染与血清可溶性肿瘤坏死因子受体水平的研究

The relationship of cervical carcinoma to STNFR level and Chlamydia trachomatis infection

目的 探讨可溶性肿瘤坏死因子受体 (STNFR)水平及沙眼衣原体 (CT)感染与宫颈癌的关系。方法 对 6 2例宫颈癌用聚合酶链反应 (PCR)法检测患者癌组织中CT ,用双抗体夹心酶联免疫吸附试验 (ELISA)检测患者血清中STNFR Ⅰ、STNFR Ⅱ ,并与正常 35名对照者进行比较。结果 宫颈癌患者组织中CT感染率明显高于正常对照组 (P <0 0 0 1) ;宫颈癌患者血清STNFR Ⅰ、STNFR Ⅱ水平较正常组织明显增高 (P <0 0 0 1) ;在宫颈癌患者血清中CT感染阳性组STNFR Ⅱ水平均高于阴性组 (P <0 0 5 )。结论 STNFR与宫颈癌的发生发展有关 ,STNFR水平的增高可能与宫颈癌人乳头状瘤病毒 (HPV)感染有关 。

Objective To explore the correlation of soluble tumor necrosis factor receptor (STNFR) and Chlamydia trachomatis (CT) with cervical carcinoma.Methods CT was detected by polymerase chain reaction (PCR) from the patient′s carcinomatous tissue;the serum levels of STNFR Ⅰ,STNFR Ⅱ were measured by sandwich ELISA in 62 cases of patients with cervical carcinoma,and 35 cases of normal women as the control.Results The positive rate of CT in the cervical tissue among the patients with cervical carcinoma was significantly higher than that among the control group ( P <0 001).The serum levels of STNFR Ⅱ of patients who were infected with CT,respectively were higher than those of patients who were not infected with CT in the cervical carcinoma cases ( P <0 05).Conclusion STNFR is associated with the genesis and development of cervical carcinoma.Increased serum STNFR level seems to be related with the CT infection in the patients with cervical carcinoma,its occurrence mechanism needs further investigation.