盐酸左氧氟沙星治疗细菌性感染114例临床观察

Clinical study on levofloxacin in the treatment of 114 cases of acute bacterial infections

目的 :评价国产盐酸左氧氟沙星注射液治疗急性细菌性感染的有效性与安全性。方法 :以盐酸左氧氟沙星注射液治疗急性细菌性感染 ,每次200mg,静脉滴注 ,每日2次 ,疗程7～14日。结果 :治疗呼吸系统、泌尿生殖系统细菌性感染114例 ,临床治愈率与有效率分别为68 42%和88 60% ,细菌清除率为94 57%。纸片药敏结果表明临床分离菌对左氧氟沙星、加替沙星、环丙沙星和司帕沙星的敏感率均较高。不良反应发生率为13 16% ,主要为恶心、呕吐、头晕、皮疹、转氨酶升高等 ,试验中未见光敏反应及其他严重不良反应。结论 :国产盐酸左氧氟沙星注射液抗菌谱广、抗菌活性强 ,治疗各种敏感菌所致的急性中。

Objective:To evaluate the safety and efficacy of domestic intravenous levofloxacin in the treatment of acute bacterial infections.Methods:A clinical trials of intravenous levofloxacin on patients with acute bacterial infections were conducted.The regimen of the group was 0.2 g,twice daily,7～14 d.The drugs were given intravenously.Results:A total of 114 patients with respiratory tract,urinary tract acute bacterial infections were treated in this trial.The overall cure rate and efficacy rate in trial were 68.42%and 88.60%respectively.The bacterial clearance rates were 94.57%.Disk agar diffusion test showed the sensitive rate of clinical isolates to levofloxacin was much higher than that to the cefetaxime.The adverse raection rates of the levofloxacin were 13.16%.The adverse events observed were mainly nausea,vomiting,dizziness rash and ALT elevation.There were no photosensitivity and other serious adverse effective.Conclusion:The results suggest that demostic levofloxacin injection with powerful antibacterial activity and wide spectrum is an effective and safe quinolone in treatment of acute bacterial infections.