选择性冠状动脉^(99m)Tc-MIBI介入心肌灌注显像评价心肌梗死后存活心肌的实验研究

EVALUATION OF VIABLE MYOCARDIUM AFTER ACUTE MYOCARDIAL INFARCTION WITH SELECTIVE 99mTc - MIBI CORONARY ANGIOCARDIOGRAM

目的 探讨选择性冠状动脉99mTc-MIBI介入心肌灌注显像检测心肌梗死后存活心肌的价值。方法 以犬的实验性心肌梗死模型为研究对象,采用自身对照方法,先后行99mTc-MIBI静息心肌灌注显像、硝酸甘油(NTG)静滴99mTc-MIBI。心肌灌注显像和选择性冠状动脉99mTc-MIBI介入心肌灌注显像,采用四点计分法对各节段核素分布进行半定量评价。结果 与NTG静息心肌灌注显像比较,选择性冠状动脉99mTc-MIBI介入心肌灌注显像对心肌梗死后存活心肌有更高的检出率[(5.1±1.5)vs(6.3±1.4)分,P<0.05]。结论 选择性冠状动脉99mTc-MIBI介入心肌灌注显像诊断存活心肌,具有准确、快速、可与冠状动脉造影同步的优点,具有实用价值。

Objective To assess selective coronary 99mTc - MIBI myocardial perfusion imaging on detecting viable myocardium after acute myocardial infarction (AMI). Methods 10 acute myocardium infarction model canines were performed 99mTc - MIBI rest myocardial perfusion imaging, NTG 99mTc - MIBI myocardial perfusion imaging intravenously and intracoronary 99mTc - MIBI myocardial perfusion imaging sequentially. The results of radionuclide distribution in myocardium were analysed by four -point counts. Results Compared with NTG 99mTc - MIBI myocardial perfusion imaging, selective 99mTc- MIBI myocardial perfusion imaging showed higher value in detecting viable myocardium [(5.1 ±1.5)vs(6.3 ±1. 4)points, P<0. 05]. Conclusion It is suggested that selective coronary 99mTc -MIBI myocardial perfusion imaging is a reliable and accurate method for detecting viable myocardium.