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Effects of interlinker sequences on the biological properties of bispecific single-chain antibodies 被引量:1

Effects of interlinker sequences on the biological properties of bispecific single-chain antibodies
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出处 《Chinese Science Bulletin》 SCIE EI CAS 2003年第21期2277-2283,共7页
基金 supported by the National"863"Hi-Tech Development Program of China(Grant No.863-102-09-04-01).
关键词 单链双榍抗体 基因工程 临床应用 生物学 连环序列 single-chain antibody, bispecific antibody, single-chain bispecific antibody, interlinker.
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  • 1张香云,钱和年,邱并生,崔恒,冯捷,黄华梁,傅天云,李文锦,王建六,周萍,李小平.6B11卵巢癌抗独特型单链抗体表达及序列分析[J].北京医科大学学报,1996,28(4):252-255. 被引量:18
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  • 5Huston JS, Levinson D, Mudgett-Hunter M, et al. Protein engineering of antibody binding sitc:Recovery of specific activiry in an anti-digoxin single-chain analog produced in E. coli.Proc Natl Acad Sci USA, 1988:85(16):5879.
  • 6Alfthan K, Takkinen K, Sizmann D, et al. Properties of a singlechain antibody containing different linker peptides. Protein Eng, 1995,8(7):725.
  • 7周萍,冯捷,钱和年,蒋欣,黄华梁.抗人卵巢癌单克隆抗体COC183-B_2轻链可变区基因的体外扩增、克隆及序列分析[J].徐州医学院学报,1998,18(3):173-175. 被引量:2
  • 8周萍,冯捷,蒋欣,黄华梁.抗人卵巢癌单克隆抗体COC183-B_2重链可变区基因的体外扩增、克隆及序列分析[J].北京医科大学学报,1998,30(3):202-204. 被引量:6

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