氯诺昔康的不良反应及其合理使用的回顾性调查

A Retrospective Study of Adverse Drug Reaction and Rational Use of Lornoxicam

目的:了解住院患者服用氯诺昔康(可塞风)的疗效、药物不良反应,促进临床合理使用。方法:回顾性观察使用氯诺昔康的29例住院患者,评价其止痛效果、药物不良反应发生及合理用药。结果:29例疼痛患者使用氯诺昔康后止痛效果确切,疼痛缓解率为100%。发生药物不良反应2例,药物不良反应发生率为6.90%;药物不良反应的发生与年龄大、合并用药不合理有关。不合理用药9例,发生率为31.03%,主要问题为用法、用量不当及合并用药不当。结论:氯诺昔康在临床上应用于镇痛,疗效确切,但要注意合理用药,避免不当的合并用药。

Objective:To study the rate of adverse drug reaction(ADR) and the rational use of lornoxicam among in-patients.Methods:All in-patients treated with lornoxicam in department of oncology in our hospital were retrospectively observed.Results:The overall efficacy of lornoxicam on pain lysis was 100%. Of 29 patients 4 ADR cases were found with a ADR rate was 6.90%. The ADR occurrence was related to older age and irrational drug use. 9 cases(31.03%) were related with irrational drug use, mainly irrational drug regimen and irrational drug combination. Conclusion:Lornoxicam is safe in clinical use, but attention should be paid on drug adverse reaction and rational use, particularly in the irrational drug combination.