摘要
探讨失血性休克复苏时肺组织中一氧化氮合酶 (NOS)活性、一氧化氮 (NO)含量的变化及牛磺酸对其的影响。新西兰种兔 2 4只随机分为三组 (n =8) :对照组、休克复苏组、牛磺酸治疗组。采用失血性休克复苏动物模型。结果发现 :休克复苏 3h肺湿重 肺干重、肺水含量、肺通透指数 (LPI)、肺泡灌洗液 (PALF)中蛋白含量、肺组织中NOS活性、NO含量均升高 (均P <0 0 1)。同时 ,血浆中NOS、LDH活性及NO含量均有显著升高 (均P <0 0 1)。预先给予牛磺酸 (静脉注射 ,4 0mg kg体重 )可显著缓解上述变化 (均P <0 0 1)。提示失血性休克复苏时NOS的激活和NO的大量释放 ,对休克复苏所致肺损伤的发生发展起重要作用 。
To investigate the changes of nitric oxide synthase (NOS)activity and nitric oxide products( NO 2 -/NO 3 -)content in lung tissue during shock resuscitation as well as the effect of taurine. Twenty four rabbits were randomly divided into 3 groups(n=8): control group, shock group and taurine group. Result showed: In shock group,lung wet/dry weight, water content, permeability index,and protein content in BALF, the activity of NOS and the content of NO 2 -/NO 3 - in lung homogenate obviously increased 3 hours after resuscitation( P <0.01). Meanwhile,the activities of NOS and LDH, the content of NO 2 -/NO 3 - in plasma increased significantly ( P <0.01). All the changes mentioned above were attenuated by intravenous injection of taurine(40mg/kg)( P <0.01). It suggest that the activation of NOS and NO release played an important role in lung injury induced by shock resuscitation and taurine has significant protective effect.
出处
《基础医学与临床》
CSCD
北大核心
2003年第5期547-550,共4页
Basic and Clinical Medicine
基金
石河子大学青年科学基金 (编号 2 0 0 2 3)
