DNA修复基因XPC PAT遗传多态与肺癌的关系

Poly(AT) polymorphism in DNA repair gene XPC and lung cancer risk

目的 探讨DNA修复基因XPCPoly(AT)多态与肺癌的关系。方法 以PCR方法分析59 7例肺癌患者和 50 9例正常人XPCPAT基因型分布 ,并比较不同基因型与肺癌风险的关系。结果正常人群中 ,XPCPAT + / +、PAT + / -和PAT -/ -基因型频率分别为 12 .4%、49.7%和 3 7.9% ,肺癌患者中分别为 11.2 %、46.7%和 42 .1% ,差异无显著性 (P =0 .3 7)。与携带至少一个XPCPAT等位基因比较 ,携带PAT + / +基因型个体患肺癌的风险并未增高 (校正OR =0 .8;95%CI为 0 .55～ 1.16)。该基因多态与吸烟无联合作用。结论 中国人肺癌风险与DNA修复基因XPCPAT多态无关。

Objective It has been shown that suboptimal DNA repair capacity is associated with cancer risk and that a poly(AT) polymorphism in XPC gene (XPC P AT) may influence DNA capacity. This study was designed to assess the relations hip between XPC PAT polymorphism and susceptibility to lung cancer in the Chines e population. Methods XPC genotypes were determined by PCR methods in 509 healthy controls and 597 patients with lung cancer. The adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariate logistic regre ssion model. Results Genotype frequencies of XPC PAT among controls were 37.9% (PAT-/-), 49.7%(PAT+/-) and 12.4% (PAT+/+), respectively. They were not si gnificantly different from those among lung cancer patients (42.1%, 46.7% and 11 .2%, respectively; P=0.37). Individuals carrying XPC PAT+/+ genotype were not at increased risk for lung cancer as compared with those with PAT+/- or PAT -/- genotype (adjusted OR, 0.8; 95% CI, 0.55～1.16). No interaction bet ween XPC genotype and smoking was observed. Conclusion Our findings indicate that the XPC PAT p olymorphism may not be associated with risk of lung cancer in the Chinese popula tion.