单剂量口灌呋喃唑酮在草鱼体内消除及组织残留研究

Studies on the depletion and residues of furazolidone in grass carp(Ctenopharyngodon idellus) after single administration

按60mg kg的剂量给草鱼灌服呋喃唑酮,用高效液相色谱法检测用药后不同时间的血浆、肝脏、肾脏及肌肉中药物浓度,然后用MCPKP药代动力学软件处理药时数据,对药物在草鱼体内消除及组织残留进行研究.结果表明:单剂量口灌呋喃唑酮在草鱼血液中主要药动学参数为:AUC3.7569μg·h mL,Cmax0.5176μg mL,t1 2α1.5249h,t1 2β22.8632h,Tpeak2.2296h,k101.0158h-1,k120.1249h-1,k210.06547h-1;给药后72h肌肉和血浆中检测不到药物,7d后肝、肾中药物消除.

It is about studies on the depletion and residues of furazolidone in Ctenopharyngodon idelles after single administration. Tissues(plasma, muscle, liver and kidney) concentration of furazolidone were measured by HPLC. The plasma concentration-time data was analyzed with MCPKP practical pharmacokinetics software. The results showed that the main parameters in the blood of grass carp were :AUC 3.756 9 μg/mL, Cmax 0.517 6 μg/mL,t_(1/2α)1.524 9 h,t_(1/2β)22.863 2 h,T_(peak)2.229 6 h,k_(10) 1.015 8 h^(-1),k_(12) 0.124 9 h^(-1),k_(21)0.065 4 7 h^(-1),At seventy-two hours after dosing, the residues of furazolidone in plasma and muscle can not be detected, but the depletion of furazolidone in liver and kidney needs seven days.