肿瘤性贫血血清Epo与Hb浓度相关性研究

Study on the relationship between serum Epo and Hb level in anemia children due to tumor

目的 :了解肿瘤患儿血清促红细胞生成素 ( Epo)水平的变化。方法 :用放射免疫分析法测定 38例急性白血病 ( AL)、1 9例恶性实体瘤患儿及 1 5例健康儿童血清 Epo水平。结果 :1急性淋巴细胞白血病 ( ALL)初治组 39.79± 1 6.2 2 m IU/m L;急性髓性白血病 ( AML)初治组 33.96± 8.1 3m IU/m L,恶性实体瘤组 35 .0 6± 1 8.68m IU/m L;对照组 1 2 .2 3± 3.1 1 m IU/m L。 Epo在 ALL、AML初治组及恶性实体瘤组的水平显著高于正常对照组 ( P<0 .0 5 ) ;2 ALL缓解组 2 1 .63±1 3.2 7m IU/m L,AML缓解组 2 5 .2 2± 5 .46m IU/m L,ALL与 AML缓解组 Epo水平仍高于正常对照组 ( P<0 .0 5 ) ,但均低于初治组 ( P<0 .0 5 ) ;3血清 Epo水平与 Hb呈明显负相关关系 ( P<0 .0 5 )。结论 :肿瘤患儿贫血的产生并非完全由于 Epo水平降低而引起 ,早期红系造血的缺陷是产生贫血的主要原因。

Objective: To investigate the level change of Epo in anemia children due to tumor.Methods:The level of Epos were checked by means of radio immunoassay in 38 cases of acute leukemia, 19 cases of deadly solid tumor and 15 cases of healthy children.Results: ①The level of Epo in ALL early treatment group was 39.79±16.22 mlU/ml, in AML treatment group was 33.96±8.13mlU/ml, in deadly solid tumor as 35.06±18.68mlU/ml, and in normal control group was 12.23±3.11mlU/ml. Tle level of Epo in ALL,AML early treatment group and deadly solid tumor group were markedly higher than that in normal control group( P <0.05).②The level of Epo in ALL relief group was 21.63±13.27mlU/ml, in AML relief group was 25.22±5.46mlU/ml. The level of Epo in ALL and AML relief group were higher than that in control group, while lower than that in early treatment group( P <0.05). ③There was negative relevance between the level of Epo and Hb( P <0.05). Conclusion:The occurrence of anemia in children with tumor is not completely due to the level of Epo decreasing, while the main reason is existed in hemopoiesis deficiency.