不同年龄妇女胫骨定量超声检测与骨代谢生化指标关系

The assessment of quantitative ultrasound technique and bone metabolic biochemical markers in women of different age groups

目的 探讨胫骨定量超声测量与血生化骨代谢指标在不同年龄组妇女中的变化趋势。方法 共4 5 7例绝经前、后妇女 ,其中绝经前组 89例 ,按年龄分为 3个亚组 :绝经前第 1组 (2 5～ 35岁 ) 2 3例 ,绝经前第 2组 (36～ 4 5岁 ) 31例 ;绝经前第 3组 (46～ 5 5岁 ) 35例。 36 8例为绝经后组 ,按绝经年限分为 :绝经后第 1组 (绝经1～ 5年 ) 88例 ,绝经后第 2组 (绝经 6～ 2 5年 ) 2 80例。采用酶联免疫吸附法 (ELISA)测定各组骨吸收指标尿胶原吡啶交联与肌酐比值 (Pyd/Cr)、骨形成指标血骨碱性磷酸酶 (BALP)、血骨钙素 (BGP)、血Ⅰ型胶原羧基末端前肽 (CICP) ,同时测定胫骨超声速率 (SOS)。结果 所有骨代谢生化指标在绝经后早期均有明显升高 ,绝经前第 3组的骨吸收指标Pyd/Cr已较绝经前其他两组明显升高。绝经后妇女的SOS值均较绝经前显著降低。 结论 骨形成指标的改变落后于骨吸收指标 ,Pyd/Cr能较早反映围绝经期骨代谢的变化 ,SOS可简便、准确地反映绝经后妇女骨量的改变。

Objective To study the changes of bone formation and bone resorption markers in women of different age groups and the assessment made by quantitative ultrasound technique given at the same time.Methods 457 women were divided into two groups according to menopause. 89 premenopause women were grouped by every 10 years of age into three subgroups, and 368 postmenopause women were divided into two subgroups. Bone formation markers and bone resorption markers were measured by enzyme linked immunosorbent assay (ELISA).Quantitative ultrasound technique was used for tibia SOS analysis.Results All markers were significantly higher in early postmenopausal group than in the premenopausal group. Pyd/Cr increased significantly in the subgroup of premenopausal women with age from 46 to 55. The value of SOS decreased in both postmenopausal subgroups.Conclusion The change of bone formation markers lag behind bone resorption markers in perimenopause women. It is likely that Pyd/Cr can reflect bone turnover more sensitively. The value of SOS can reflect the bone mass changes in postmenopausal women accurately and conveniently.