性腺切除对家兔骨代谢及骨量的影响(英文)

Experimental studies of bone mass loss after ovariectomized and orchidectomized rabbits

目的:研究切除家兔卵巢、睾丸后骨丢失情况。方法:选择48只家兔,20只切除卵巢,20只切除睾丸,对照组各4只家兔。手术后4,7和10周分别测定血清中钙、磷、碱性磷酸酶、肌苷、骨钙素含量和尿内羟脯氨酸,10周后处死家兔,测定胫骨骨矿含量,骨沉积速度、骨皮质宽度和类骨质宽度。结果:卵巢切除组(OVX)与睾丸切除组(ORX)比较,血清肌苷(μmoL/L)在4周时分别为82±4,66±6;7周时分别为78±4,40±3。差异有显著性意义(P<0.01)。而尿内羟脯氨酸和骨钙素含量OVX比ORX降低。OVX骨沉积速度、类骨质宽度大于ORX,两组之间差异有显著性意义。结论:骨质丢失与雌激素之间有密切关系;睾丸切除后对骨质影响时间较短,7周后对骨质影响逐渐消失。

AIM:To study bone mass loss after rabbits being ovariectomized and being orchidectomized. METHODS: Twenty Four females and 24 males rabbits were selected in the study,20 rabbits was performed orchidectomy and 20 rabbits ovariectomized,4 females and 4 males rabbits for control group.It were measured that Ca, P, AKP, Cr,BGP and HYP levels in serum on 4 weeks, 7 weeks and 10 weeks.It also were measured that BMC and bone morphological after sacrifice all rabbits .RESULTS:The Cr levels(μ moL/L) of OVX group were (82± 4) and (78± 4) significantly higher than those of ORX group[(66± 6) and (40± 3),P< 0.01],but HYP and BGP decreased in 4 weeks and 7 weeks.Bone deposition velocity(BDV) of OVX group were faster than those of ORX group.The osteoid width(OW) of OVX group was wider than one of ORX group.There was a significant difference (P< 0.01).