电针与氟西汀治疗抑郁症疗效的对照研究

Comparative study of electroacupuncture and fluoxetine for treatment of depression

目的 对比电针与氟西汀治疗抑郁症的疗效。方法 将 95例抑郁症患者随机分为电针组 ( 31例 )、氟西汀组 ( 32例 )及安慰剂组 ( 32例 )。电针组采用智能电针仪治疗 ,用抗抑郁波型 ,以毫针针刺百会、印堂穴 ,强度 2～ 3V ,4 5min/次 ,1次 /d ,每周 5次 ,同时服安慰剂 ;氟西汀组予氟西汀胶囊 2 0mg/d ,并接受模拟电针 ;安慰剂组用安慰剂并接受模拟电针 ;疗程 6周。于治疗前及治疗中每 2周评定 1次汉密尔顿抑郁量表 (HAMD)、Asberg抗抑郁药副作用量表、抑郁自评量表 (SDS)、临床总体印象量表 (CGI)。结果 治疗第 6周末 ,电针组的HAMD总分 [( 10 19± 5 88)分 ]低于安慰剂组[( 13 88± 8 2 9)分 ;P <0 0 5 ],SDS评分 [( 5 3 0 2± 9 6 7)分 ]亦低于安慰剂组 [( 6 0 0 0± 12 89)分 ;P <0 0 5 ];安慰剂组CGI中的病情严重程度 [( 3 16± 1 32 )分 ]重于电针组 [( 2 4 2± 1 0 3)分 ]和氟西汀组[( 2 5 6± 1 13)分 ;P <0 0 5 ],总体进步分 [( 2 84± 1 2 7)分 ]低于电针组 [( 2 10± 0 94 )分 ;P <0 0 1]和氟西汀组 [( 2 2 5± 1 0 8)分 ;P <0 0 5 ];电针组与氟西汀组各项评分的差异均无显著性。三组Asberg量表评分差异无显著性。

Objective To compare the therapeutic effect of electroacupuncture (EA) and fluoxetine for treating depression Methods Ninety five outpatients with major depressive episode were randomly assigned into three different treatment groups: EA (31), fluoxetine (32) and control group (32) The EA group was given acupuncture at Baihui and Yintang points and placebo capsules; fluoxetine group given fluoxetine 20 mg daily and sham acupuncture; and control given placebo capsules and sham acupuncture All treatment lasted for 6 weeks All subjects were rated every 2 weeks with the Hamilton Rating Scale for Depression (HAMD), Asberg Rating Scale for Side Effects(SERS), Self rating Depression Scale (SDS), Clinical Global Impression (CGI) for evaluating the therapeutic effect Results At the end of the 6 week treatment, there were better improvement in EA group compared to controls on both the HAMD score (10 19± 5 88 vs 13 88±8 29; P< 0 05) and SDS score (53 02±9 67 vs 60 00±12 89; P< 0 05), and the severity of illness on CGI score was worse in controls (3 16±1 32) than in EA (2 42±1 03) and fluoxetine (2 56±1 13) groups ( P< 0 05) There was no significant difference between the EA and fluoxetine groups on any of the rating scores Conclusion EA is at least as efficacious as fluoxetine for treating patients with major depressive disorder