施普善与胞二磷胆碱合用治疗新生儿缺血缺氧性脑病84例疗效观察

Study on the efficacy of cerebrolysin and CTC in treatment of 84 patients with HIE

目的:探讨施普善与胞二磷胆碱合用对新生儿缺血缺氧性脑病的临床疗效与安全性。方法:84例病人随机分为治疗组(47例)和对照组(37例),治疗组在一般治疗基础上加用施普善(脑活素)1ml/kg和胞二磷胆碱(CTC)100～125mg/d加入10%葡萄糖注射液静滴,qd,疗程为7d。对照组在一般治疗基础上加用胞二磷胆碱(CTC)100～125mg/d加入10%葡萄糖注射液静滴,qd,疗程为7d。结果:治疗组痊愈率为76.6%,有效率为95.7%;对照组痊愈率为35.1%,有效率为75.7%。经统计学处理两组有效率和显效率均有显著性差异(P<0.05)。结论:施普善是治疗新生儿缺血缺氧性脑病较理想的药物。

Object To evaluate the efficacy of Cerebrolysin and CTC in the treatment of the HIE.Method84patients were di-vided into two groups:Group Cerebrolysin consisted of 47patients with the Cerebrolysin1ml/kg and CTC100-125mg /d for 7d with routine treatment.Group CTC consisted of 37patients with CTC100～125mg /d for 7d with routine treaatment;Results The overall effective rates of Cerebrolysin and CTC were76.6%and35.1%,the effective rates of Cerebrolysin and CTC were95.7%and75.7%.Obvious ADRs were observed in effective rate between Cerebrolysin and CTC in the study.Conclusion Cerebrolysin is effective in treatment of HIE.