奥美拉唑联合硫糖铝预防重症脑卒中并发应激性上消化道出血

Omeprazole combined with sucralfate in preventing upper alimentary tract hemorrhage followed serious stroke

目的:探讨奥美拉唑联合硫糖铝在预防重症脑卒中并发症应激性上消化道出血中的疗效。方法:符合入选条件的病人180例,分为2组,在常规治疗基础上,奥美拉唑组100例,给予奥美拉唑20mgqd,硫糖铝750mg每日3次,两药错开口服或经胃管注入,疗程10～14d;西咪替丁组80例,给予西脒替丁0.4g,加入氯化钠注射液40ml静滴,每日2次,疗程10～14d;对2组病人上消化道出血的发生率进行对比。结果西脒替丁组应激性上消化道出血的发生率为30%,明显高于奥美拉唑组12%,差异有非常显著意义(P<0.01)。结论:奥美拉唑联合硫糖铝是一种非常有效的预防重症脑卒中并发应激性上消化道出血的方法。

Objective To study the effect of omeprazole com bined with sucra lfate in preventing upper alimentary tract hemor-rhage followed serious stroke.Method One hundred and eighty patients were divided into two groups.One hundred patients of omeprazole group were given omeprazole(20mg qd)and sucralfate(750mg ,Tid)for 10～14d.Eighty patients of cimetidine group were given cimetidine0.4g in0.9%sodium chloride injection40ml ,iv Bid,for 10～14d.The rate of upper alimentary tract hemorrhage and death rate of two groups was contrasted.Result The occurent rate of upper alimentary tract hemorrhage rate of cimetidine group was30%,it was higher than that of omeprazole group(12%).There was significant difference(P<0.01).Con clusion Omeprazole com-bined with sucralfate is an effective method to prevent upper alimentary tract hemorrhage followed serious stroke.