薏苡仁甘草汤防治尖锐湿疣复发68例临床观察

Effect of Yiyiren Gancao Tang in Preventing and Treating Condyloma Acuminatum: An Observation of 68 Cases

【目的】观察薏苡仁甘草汤对预防尖锐湿疣复发的疗效及其对相关免疫指标的干预作用,为预防微波除疣后的尖锐湿疣复发寻找有效的治疗药物。【方法】34例微波除疣后的尖锐湿疣(CA)患者内服薏苡仁甘草汤,服药后观察其CA复发率情况;并采用双抗夹心法及玫瑰花环法,分别于用药前及用药后动态观察血液中白细胞介素--2(IL-2)、外周血T淋巴细胞亚群等免疫指标的变化,并与安慰剂组(34例)作比较。【结果】治疗组的复发率为20.5％,其防治CA复发的效果明显优于安慰剂组的47.0％(P<0.05);治疗组经治疗后血清IL-2,外周血T淋巴细胞亚群等免疫指标均有明显改善(P<0.05或P<0.01),而安慰剂组则变化不明显(P>0.05)。【结论】薏苡仁甘草汤能有效阻止和减少CA的复发,改善患者的免疫功能。

【Objective】To observe the effect of Yiyiren Gancao Tang (YGT) in preventing the recurrence of condyloma acuminatum (CA) after microwave therapy and to explore its influence on relative immunological indexes. 【Methods】 Sixty-eight cases of CA were randomized into two groups: 34 cases (Group A) were treated with YGT and other 34 with placebo decoction (Group B) after microwave therapy. The recurrence rate in the two groups were observed; serum interleukin-2 (IL- 2) level and subtypes of T lymphocyte counting in peripheral blood were detected with double antibody sandwich immunoassay and rosette formation test before and after treatment.【Results】The recurrence rate was 20.5% in Group A and 47.0% in Group B (P< 0.05). After treatment, serum IL - 2 level and subtypes of T lymphocyte counting were obviously improved in Group A (P<0.05 or P<0.01) and no obvious changes were found in Group B ( P>.05). 【Conclusion】YGT can reduce the recurrence of CA, improve the immune function and is practical in clinics.