肺癌危险度与室内氡关系研究:中国两项研究的汇总分析结果

Risk of Lung Cancer and Residential Radon:Pooled Results of Two Studies in China.

目的 居室氡暴露是导致肺癌死亡的第二位重要原因,这是地下矿工氧暴露研究的外推结果。本分析就是为了验证此预测的正确性。方法 中国进行的两项居室氡暴露肺癌病例-对照研究共包括1050肺癌病例和1996名对照,把这些数据汇总在一起进行分析。结果 根据线性模型,在95％置信区间情况下,每100Bq/m^3的附加比值比(EOR)为0.133(0.01,0.036)。对在现住所居住30a以上的调查对象进行分析,EOR值为0.315(0.07,0.91)。此估算值与矿工数据外推值及北美和欧洲室内氡研究结果类似。结论 在众多居室中普遍存在的氡浓度长期暴露,会使肺癌危险度增加。

Objective To verify the prognosis that miners' exposure to radon is the second leading cause of lung cancer. Methods We collected data from two case - control studies of residential radon representing two large radon studies conducted in China. The studies included 1 050 lung cancer cases and 1 996 controls.Results Based on a linear model, the excess odds ratio ( EOR) with 95% confidence intervals ( CI ) at 100 Bq/m3 was 0.133 (0.01,0.36) .For subjects living in the current home for 30 years or more, the EOR was 0.315 (0.07,0.91) . EOR estimates were similar to those in the extrapolations from miner data and consistent with residential radon studies in North American and Europe. Conclusion Long - terra radon exposure at concentrations found in many houses increases lung cancer risk.