缬沙坦防止急性心肌梗死患者左室重构的临床分析

VALSARTAN IN LEFT VENTRICULAR REMODELING OF CASES WITH ACUTE MYOCARDIAL INFARCTION

目的 探讨缬沙坦同急性心肌梗死患者左室重构的临床关系。方法 采用随机、单盲自身对照及组间对照方法,将96例急性心肌梗死患者分为缬沙坦组50例,常规治疗组46例,治疗1-6个月后,观察比较二组治疗前后临床疗效,行二维超声心动图检查,采用Simpson法观察左室射血分数(LVEF),及左室收缩末期容积指数(LEV-SI),左室舒张末期容积指数(LEDVI)的变化。结果 缬沙坦组治疗后LVEF,LESVI,LEDVI与对照组比较差异有高度显著性(P<0.01)。结论 缬沙坦能有效防止心肌梗死后左室重构,值得临床推广。

Objective To evaluate the relation between valsartan and left ventricular remodeling on patients with acute myocardial infarction. Methods Random and single blind contrast design during the period of 6 months was performed in cases with acute myocardial infarction in valsartan group(n= 50) and the control (n=49) .All cases underwent echocardiogram on the 7th , the 30th and the 180th day after AMI. The left ventricular end - systolic and end - diastolic volumes (LESV, LEDV) were calculated by computer software according to a modified Simpson's rule. The volume indexes (ESVI, EDVI) were obtained by dividing the volume of the body surface area at each time point. The left ventricular ejection fraction (LVEF) was calculated as stroke volume/end - diastolic volume. Results The clinical prognosis of cases in valsartan group was better than that in the control. The levels of LVEF, ESVI and EDVI in valsartan group were significantly ameliorated compared with those of the control (P<0. 01 ). Level of No had significant difference in biochemistry parameters between two groups(P > 0. 05). Conclusion Valsartan has obvious effects on preventing the left ventricle remodeling in cases with acute myocardial infarction.