谷氨酰胺在慢性阻塞性肺病营养支持中的应用

L-glutamine in the Nutritional Support for Patients with Chronic Obstructive Pulmonary Disease

目的研究谷氨酰胺(Gln)在慢性阻塞性肺病(COPD)患者营养支持中的作用。方法对32例COPD合并营养不良患者进行总能量摄入均为静息能量消耗(REE)的1.5倍,其中蛋白质占20%,脂肪占30%,碳水化合物占50%的营养支持。A组(n=14)为Gln治疗组,每日口服Gln30g鸦B组(n=18)为对照组。结果A组肱三头肌皮褶厚度、前白蛋白、体脂等营养参数较B组明显改善,最大呼吸肌力显著提高,A组REE却出现显著下降(P<0.05～0.01)。结论Gln不仅可以显著改善COPD患者的营养状况和呼吸肌力量,而且能降低患者的能量消耗,提高对COPD患者营养支持的有效性。

Objective To study the effect of L-ghutamine in the nutritional support for patients with chronic obstructive p ulmonary disease(COPD)accompanied malnutrition.Methods Thirty-two cases with COPD were supportive treated in total calorie of1.5resting energy expenditure(REE)and were randomly divided into A group( n= 14)and B group( n= 18).While A group orally administered30g L-glutamine per day supplementarily and B group were control subjects.Results The nutritional parameters such as triceps skinfold thickness(TSF),prealbumi n(PAIb),fat mass(FM)improved,maximal respiratory muscle strength increased and REE decreased significantly in A group( P< 0.05～0.01).Conclusions L-glutamine is helpful in effectiveness of nutritional support in COPD,as it can significantly improve patients' nutritional parameters and decrease their en ergy expenditure.