多相催化合成月桂氮酮的工艺研究

Study of Laurocapram Synthesis on Heterogeneous Catalyst

以硫酸法精制的工业溴代十二烷为原料,甲苯作溶剂,用KOH-KF/Al2O3作催化剂,采用分水操作,多相催化合成月桂氮酮,在反应温度90°C,反应时间3.5h的反应条件下,月桂氮酮收率达92.3%,纯度>98.5%。该方法工艺简单,操作方便,成本低,催化剂分离易,产品无需进一步精制,易于实现工业化。

Laurocapram was synthesized using industrial grade 1-bromododecane as raw material after purification with sulphuric acid,and methylbenzene as solvent, and potassium hydroxide and potassium fluoride supported on alumina as catalyst. The water was separatd during operation. The content of laurocapram in the product was over 98.5% and the yield of laurocapram was 92.3% after reacting 90 °C for 3.5 h. The method is simple and convenient. The production cost is low and the separation of the catalyst from the system is easy. The product does not need further purification, so the process is suitable for industrialization.