不同类型激素依赖型哮喘患者糖皮质激素受体的分析与比较

Clinical characteristics and abnormality in glucocorticoid receptor in different kinds of steroid-dependent asthma

目的 探讨激素依赖型 (SD)哮喘临床特征和单个核细胞 (PBMC)糖皮质激素受体 (GR)的水平。方法2 6例激素依赖型哮喘 ,口服泼尼松 2 0mg/d ,疗程 7天 ,依据肺功能的变化 ,分为激素敏感型 (SS)哮喘 11例和激素抵抗型 (SR)哮喘 15例 ,比较两型临床资料、基础肺功能和PBMC的GR水平。结果 SS型和SR型哮喘在病史、肺功能和血嗜酸粒细胞方面差异无统计学意义 ,SR型哮喘PBMC的GR水平明显低于SS型哮喘 (P <0 .0 0 2 )。结论SR型激素依赖型哮喘GR水平异常低下是其特征。

Objecctive To investigate the clinical characteristics and glucocorticoid receptor(GR) in peripheral blood mononuclear cells(PBMC) of steroid-depentent(SD) asthma.Methods Twenty-six patients with SD asthma,taking prednisone 20 mg/d for 7 days,were dividided into two groups,one was 11 patients with steroid-sensitive(SS) asthma,another was 15 patients with steroid-resistant(SR) asthma according to pulmonary function.Clinical data,baseline pulmonary function and glucocorticoid-receptor were compared between the two groups.Results There was no significant difference between SR and SS asthma in history,pulmonary function and eosinphils,but the number of GR in PBMC from SR asthmatics was significantly less than that from SS asthmatics (P< 0.002).Conclusion Low GR is the characteristic of SR asthma.