食管癌放化疗前后可溶性肿瘤坏死因子受体变化

The Levels of Soluble Tumor Necrosis Factor Receptor in Patients with Esopha geal Cancer before and after Radiochemotherapy

[目的]探讨食管癌患者放化疗前后血清可溶性肿瘤坏死因子受体水平的变化及其与疗效的关系。[方法]采用双单抗夹心酶联免疫吸附法,检测60例食管癌患者放化疗前和结束时血清sTNFR鄄Ⅰ和sTNFR鄄Ⅱ的水平变化,并观察其与肿瘤消退的关系。[结果]食管癌患者sTNFR鄄Ⅰ水平明显高于健康人(P<0.001),且放化疗后水平较治疗前明显下降;sTNFR鄄Ⅱ显著低于健康人(P<0.001),放化疗后有显著升高。[结论]同时检测血清sTNFR鄄Ⅰ和sTNFR鄄Ⅱ有助于判断肿瘤消退情况和评价疗效。

To explore the l ev els of soluble tumor necrosis factor receptor(sTNFR)measured in patients with es ophageal cancer before and after radiochemotherapy and the impact on response to therapy.sTNFR-Ⅰand sTNFR-Ⅱwere measured by ABC-ELISA assay in60pat ients with esophageal cancer before and after ra-diochemotherapy.Levels of them were compared with tumor regression.The level of serum sTNFR-Ⅰwas si g-nificantly higher in patients with esophageal cancer than that in controls.Th e level of sTNFR-Ⅰdecreased after ra-diochemotherapy.Yet the level of sTNFR-Ⅱin patients was lower than that in controls.After radiochemotherapy it in-cre ased.[Conclusion]The serum level of sTNFR-Ⅰand sTNFR-Ⅱis useful to evaluate tumor response to ra-diochemotherapy in patients with esophageal cancer.