杯[4]芳烃半冠醚的合成

The synthesis of calix[4]arene semi-crown ethers

用 2 5 ,2 7 二 ( 2 溴乙氧基 ) 2 6,2 8 二羟基 5 ,1 1 ,1 7,2 3 四 ( 1 甲基乙基 )杯 [4]芳烃 1与苯酚衍生物反应合成了一系列杯 [4]芳烃半冠醚化合物 2 ,用这种方法合成杯芳烃冠醚不需要柱层析 ,只通过重结晶即可得到高产率 ( 75 %～ 90 % )的化合物 .反应产物的结构和性能都经FT IR ,1HNMR ,13 CNMR ,MS等进行表征 .实验结果表明 :所得杯芳烃半冠醚均处于锥形构象 .

The calix[4]arene semi-crown ethers were synthesized by the reaction of 25,27-di(2-bromoethoxy)-26,28-dihydroxy-5,11,17,23-tetrakis(1-methylethy1) calix[4]arene with phenol derivatives in 75～90*!% yield by recrystallization instead of column chromatography. The structure of the final products and its properties were characterized by FT-IR, 1HNMR, 13CNMR, MS. The results indicated that all the calix[4]arene semi-crown ethers were in the cone conformation.