甲基取代的手性环酯化合物的螺旋结构与旋光性分析

Studies on the Helical Structure and Optical Rotation of Methyl Substituted Chiral Cyclic Ester Compounds

利用螺旋片段判定规则 ,结合 X射线衍射结构图及模型结构 ,对 4个大环酯类化合物及甲基取代产物的螺旋结构与旋光性进行了定量分析 ,检测结果证明了理论分析的正确性 ;对旋光值变化规律给予了合理解释 .

Four cyclic esters(1—4) and four cyclic esters substituted by methyl(5—8) were synthesized and their values of optical rotation were determined by polarimeter. The relationships of their optical active behavior and helical structure were investigated with the Rules Finding out Helical Segment combining X-ray structure image and its model structure. The variation of optical rotation value was analyzed. The experimental results accord with the quantitative analysis. It is proved that the optical ratation of compound is determined by the net optical value of the molecule and the Rules Finding Out Helical Segment can be applied to the analysis of the chiral cyclic ester.