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混合配体配合物钯(Ⅱ)-联喹啉-苯乙基丙二酸根与DNA作用研究 被引量:11

Study on the Interaction of Mixed Ligand Complex Palladium(Ⅱ )-biquinoline-phenethylmalonate with DNA
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摘要 Chemical Department,Liaoning University,Shenyang110036)abstract:( 3 Chemistry Department,Northeast Normal University,Changchun130024)abstract:The mixed l igand complex[Pd(biqu)abstract:(pmal)abstract:]·H 2 O(where biqu is2,2’-biquinoline,pmal is phenethylmalonate)abstract:has been synthesi zed and its interaction with sperm DNA was determined by fluorescent spectra?UV -Vis spectra and CD-spectra.The binding constant(K b )abstract:of the complex and sperm DNA is1.26×10 4 and its interaction with pBR322plasmid DNA was also determined by gel electr ophoresis.The results show that the complex interact with DNA mainly by Chemical Department,Liaoning University,Shenyang110036)abstract:( 3 Chemistry Department,Northeast Normal University,Changchun130024)abstract:The mixed l igand complex[Pd(biqu)abstract:(pmal)abstract:]·H 2 O(where biqu is2,2'-biquinoline,pmal is phenethylmalonate)abstract:has been synthesi zed and its interaction with sperm DNA was determined by fluorescent spectra?UV -Vis spectra and CD-spectra.The binding constant(K b )abstract:of the complex and sperm DNA is1.26×10 4 and its interaction with pBR322plasmid DNA was also determined by gel electr ophoresis.The results show that the complex interact with DNA mainly by intercal
出处 《无机化学学报》 SCIE CAS CSCD 北大核心 2004年第2期191-194,共4页 Chinese Journal of Inorganic Chemistry
基金 辽宁省自然科学基金资助项目(No.20022018) 沈阳化工学院拔尖人才基金资助项目。
关键词 混合配体 钯配合物 联喹啉 苯乙基丙二酸根 DNA 相互作用 脱氧核糖核酸 生物活性 抗肿瘤活性 palladium(Ⅱ) biquinoline phenethylmalonate complex DNA
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