氨曲南治疗60例老年下呼吸道细菌感染的多中心随机对照研究

A randomized controlled clinical study of aztraonam in treatment of 60 elderly patients with low respiratory tract bacterial infections

目的 :评价氨曲南治疗老年下呼吸道细菌感染的疗效和安全性。方法 :老年人下呼吸道细菌感染 12 1例 ,随机分氨曲南组 6 0例 ,用氨曲南2 .0 g ,加入氯化钠注射液 10 0mL中 ,iv ,gtt ,q 12h ,疗程 7～ 14d ;头孢他啶组 6 1例 ,用头孢他啶2 .0 g,加入氯化钠注射液 10 0mL中 ,iv ,gtt ,q 12h ,疗程 7～ 14d。结果 :氨曲南组和头孢他啶组有效率分别为 83%和 80 % ,痊愈率分别为 5 8%和5 4% ,差异无显著意义 (P >0 .0 5 )。 2组细菌清除率分别为 85 %和 82 % ,细菌阴转率分别为 82 %和82 % ,差异无显著意义 (P >0 .0 5 ) ;2组不良反应发生率分别为 2 %和 3% ,实验室检查异常发生率分别为 3%和 3% ,均系轻度呈一过性 ,差异无显著意义 (P >0 .0 5 )。结论 :氨曲南治疗老年下呼吸道细菌感染的安全。

AIM: To evaluate the efficacy and safety of aztraonam in the treatment of elderly patients with low respiratory tract bacterial infections. METHODS: One hundred and twenty-one elderly patients with lower respiratory tract infections were randomly divided into 2 groups including 60 patients in aztraonam group and 61 patients in ceftazidime group. The aztraonam group was treated with aztraonam 2.0 g in sodium chloride injection 100 mL, iv, gtt, q 12 h for 7-14 d, the ceftazidime group was treated with ceftazidime 2.0 g in sodium chloride injection 100 mL. iv, gtt, q 12 h for 7-14 d. RESULTS: The total efficacy rate was 83 % in the aztraonam group and 80 % in the ceftazidime group, whereas the cured rate was 58 % and 54 %, respectively. The bacterial clearance rate was 85 % and 82 %, respectively. The adverse reaction rate was 2 % and 3 %, respectively, and laboratory abnormality rate was 3 % and 3 %, respectively. The differences between two groups were not statistical significant (P>0.05). CONCLUSION: Aztraonam is a highly effective and safe agent for the treatment of elderly patients with lower respiratory tract bacterial infections.