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Skp2在人类恶性肿瘤中的研究进展 被引量：5

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摘要 Skp2是泛素连接酶复合物的底物识别序列 ,对正常细胞周期起调控作用 ,在多数恶性肿瘤中表达增高。研究发现Skp2与肿瘤的预后、恶性进程、治疗均有密切关系。现就Skp2与恶性肿瘤的关系作一综述。
作者 朱晓峰 吕会增 李汉贤
机构地区 南华大学第一附属医院肿瘤外科
出处 《国外医学（肿瘤学分册）》 2004年第1期7-10,共4页 Foreign Medical Sciences (Cancer Section)
关键词 SKP2 恶性肿瘤 研究进展 人类 泛素连接酶复合物
分类号 R730.2 [医药卫生—肿瘤]
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参考文献29

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  • 3Schulman BA, Carrano AC, Jeffrey PD, et al. Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 ctmaplex. Nature, 2000, 408(6810) :381-386.
  • 4Nakayarna K, Nagahama H, Minamishima YA, et al. Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kipl ),polyploidy and centrosome overduplication. EMBO J, 2000,19(9) :2069-2081.
  • 5Ezoe S, Matsumura I, Nakata S, et al. GATA-2/estrogen receptor chimera regulates cytokine-dependent growth of hematopoietic cells through accumulation of p21 (WAF1) and p27 (Kipl) proteins.Blood, 2002,100 ( 10 ) : 3512-3520.
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同被引文献62

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国外医学（肿瘤学分册）
2004年 第1期

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