期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

甾体类激素受体在乳腺癌发生与发展中的变化

下载PDF
导出
摘要 甾体类激素如雌激素和孕激素是调节正常乳腺组织发育的重要内分泌因素 ,同时也在诱导乳腺癌变中发挥重要作用。甾体类激素通过相应受体的介导对其靶细胞进行作用 ,这些甾体类激素受体在乳腺癌的发生和进展过程中发生了一系列有意义的变化 ;另外近年还发现了新的雌激素受体 (ER)亚型ER β。这些发现为研究乳腺癌发生和内分泌治疗耐药机制提供了新的线索。
作者 柳光宇 邵志敏 沈镇宙
机构地区 复旦大学附属肿瘤医院乳腺外科
出处 《国外医学（肿瘤学分册）》 2004年第1期52-56,共5页 Foreign Medical Sciences (Cancer Section)
关键词 甾体类激素受体 乳腺癌 肿瘤发生 孕激素 雌激素
分类号 R737.9 [医药卫生—肿瘤]
  • 相关文献

参考文献21

  • 1温险峰,沈赞,邵志敏,沈镇宙.乳腺癌中雌激素受体亚型对血管内皮细胞生长因子表达的影响[J].中华外科杂志,2002,40(3):175-176. 被引量：6
  • 2Allred D, Mohsin S, Fuqua S. Histological and biological evolution of human premalignant breast disease, Endocr Relat Cancer, 2001,8(1):47-61,.
  • 3Bussolati G, Bongiovanni M, Cassoni P, et al. Assessment of necrosis and hypoxia in ductal carcinoma in situ of the breast: basis for a new classification, Virchows Arch, 2000,437 ( 4 ) : 360-364.
  • 4Engels K, Fox S, Whitehouse R, et al. Distinct angiogenic patterns are associated with high-grade in situ ductal carcinomas of the breast. J Pathol, 1997,181(2) :207-212,.
  • 5Koemer F, Oyama T, Kurosumi M, et al, Ovarian hormone receptors in human mammary stromal cells. J Steroid Biochem Mol Biol,2001,78 (3) : 285 -320.
  • 6Lawson J, Field A, Champion S, et al. Low oestrogen receptor alpha expression in normal breast tissue underlies low breast cancer incidence in Japan. Lancet, 1999,354(9192) : 1787-1788.
  • 7Shoker B, Jarvis C, Sibson D, et al, Oestrogen receptor expression in the normal and precancerous breast. J Pathol, 1999, 188(3):237-244.
  • 8Clarke R, Howell A, Potten C, et al. Dissociation between steroid receptor expression and cell proliferation in the human breast. Cancer Res, 1997,57(22) :4987-4991.
  • 9Shoker B, Jarvis C, Clarke R, et al. Estrogen receptor positive proliferating cells in the normal and precancerous breast. Am J Pathol,1999,155(6) : 1811-1815,.
  • 10Murphy L, Simon S, Parkes A, et al, Altered relative expression of estrogen receptor eoregulators during human breast tumorigenesis.Cancer Res, 2000,60 (22) : 6266-6271,.

二级参考文献9

  • 1Paech K,Webb P,Kuiper GG,et al.Differential ligand activation of estrogen receptors ERαand ERβat AP1 sites[].Science.1997
  • 2Linderholm B,Grankvist K,Wilking N,et al.Correlation of vascular endothelial growth factor content with recurrences, survival, and first relapse site in primary node-positive breast carcinoma after adjuvant treament[].Journal of Clinical Oncology.2000
  • 3Kuiper GG,Enmark E,Pelto-Huikko M,et al.Cloning of a novel receptor expressed in rat prostate and ovary[].Proceedings of the National Academy of Sciences of the United States of America.1996
  • 4Ruohola JK,Valve EM,Karkkainen MJ,et al.Vascular endothelial growth factors are differentially regulated by steroid hormones and antiestrogens in breast cancer cells[].Molecular and Cellular Endocrinology.1999
  • 5Gabrilovich DI,Chen HL,Girgis KR,et al.Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells[].Nature Medicine.1996
  • 6Hyder SM,Chiappetta C,Murthy L,et al.Selective inhibition of estrogen-regulated gene expression in vivo by the pure antiestrogen ICI 182, 780[].Cancer Research.1997
  • 7Hyder SM,Nawaz Z,Chiappetta C,et al.Identification of functional estrogen response elements in the gene coding for the potent angiogenic factor vascular endothelial growth factor[].Cancer Research.2000
  • 8Speirs V,Kerin MJ.Prognostic significance of estrogen receptor beta in breast cancer[].British Journal of Surgery.2000
  • 9Johns A,Freay AD,Fraser W,et al.Disruption of estrogen receptor gene prevents 17 beta estradiol-induced angiogenesis in transgenic mice[].The Journal of Endocrinology.1996

共引文献5

国外医学（肿瘤学分册）
2004年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部