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红霉素抗菌作用及细菌产生红霉素抗性的机制 被引量:14

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摘要 红霉素是一类广谱的大环内酯类抗生素 ,随着红霉素在临床上的大量使用 ,红霉素也和其他抗生素一样出现了病原菌耐药性问题。从分子水平上将红霉素的抗菌机制与细菌产生耐药性机制联系起来对研制新一代的红霉素抗生素起指导性作用。红霉素通过从空间上阻滞新生肽链的延伸和促进pt -tRNA的脱落而起抗菌作用 ,而细菌则通过影响红霉素在胞内的积累、破坏红霉素的结构。
出处 《国外医药(抗生素分册)》 CAS 2004年第1期12-16,33,共6页 World Notes on Antibiotics
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