退高黄汤对实验性胆汁淤积大鼠肝组织病理变化的影响

Influence of “Tuigaohuang Decoction” on Liver Tissue in Rats of Experimental Cholestasis

为观察退高黄汤对实验性肝内胆汁淤积大鼠肝组织病理变化的影响 ,将 4 8只SD大鼠随机分为正常组、模型组、退高黄汤低剂量组、中剂量组、高剂量组和赤丹退黄组。除正常组外 ,其余各组连续灌胃给药 7天后 ,ANIT诱发肝内胆汁淤积模型。 4 8小时后取各组大鼠肝脏右叶作半定量分析和光电镜下病理学观察。结果 :与模型组比较 ,治疗各组病变程度均极显著好转 (P <0 0 1) ;与低剂量组比较 ,中剂量及高剂量组病变程度明显减轻 (P <0 0 5 )。

To observe the influence of “Tuigaohuang Decoction” on liver tissue in rats of experimental cholestasis, 48 rats were randomized into six groups: group A in which no treatment was given, group B, group C in which low dosage of “Tuigaohuang Decoction” was given, group D in which moderate dosage of “Tuigaohuang Decoction” was given, group E in which high dosage of “Tuigaohuang Decoction” was given, and group F in which “Chidan Tuihuang Granule” was given. Except group A, the other groups were given corresponding medicines for 7 days and then additionally administered ANIT to induce cholestasis. Forty-eight hours later, the rats' right liver was taken to make semi-quantitative analysis and observe electronically and optically. Results: Compared to group B, the liver lesion in other groups were obviously improved (P<0.01); compared to group C, the lesion in groups D and E was obviously relieved (P<0.05). It is indicated that “Tuigaohuang Decoction” can improve the liver tissue in rats of experimental cholestasis.