摘要
以新戊酰氯为原料,经酯化、酰氯化、酰胺化、脱苄基,与氢氧化钠成盐制成西维来司钠,1,经工艺改进,多步收率有较大提高,总收率47.9%。N-(2-氨基苯甲酰基)甘氨酸苄酯(4),4是以对甲苯磺酸、甘氨酸、苯甲醇为原料,经酯化、酰胺化、还原制得,总收率91.7%。
Sivelestat sodium was synthesized from pivaloyl chloride via esterification, acyl chloridization amidation, debenzylation, and then salt formation. The reaction conditions were improved and the total yield was 47.9%. _N_-(2-aminobenzoyl) glycine benzyl ester(4), 4 was synthesized from _p_-toluenesulfonic acid, glycine and benzyl alcohol via esterification, amidations and reduction with an overall yield of (91.7%.)
出处
《化学世界》
CAS
CSCD
北大核心
2004年第1期29-31,25,共4页
Chemical World
