重症肌无力患者血清titin抗体

Serum Anti-titin Antibody in Patients with Myasthenia Gravis

目的探讨血清抗titin抗体对重症肌无力合并胸腺瘤诊断的临床意义。方法用ELISA法分别测定正常对照、重症肌无力、重症肌无力合并胸腺瘤患者及非重症肌无力胸腺瘤患者血清titin抗体及乙酰胆碱受体抗体,并比较其临床意义。结果与重症肌无力患者相比,重症肌无力合并胸腺瘤患者的血清titin抗体阳性率明显增高,分别为3%和94%,且titin抗体阳性的重症肌无力病情较重。非重症肌无力胸腺瘤患者血清中亦可检出titin抗体。结论titin抗体检查对于重症肌无力合并胸腺瘤的诊断及判定预后具有重要临床意义。

To study the clinical significance of serum anti-titin antibody level in the diagnosis of myasthenia gravis(MG)with thymoma. Method The serum anti-titin antibody was analysed by ELISA method in 40 cases of health control group, 90 cases of MG, 17 cases of MG with thymoma and 7 cases of no-MG thymoma. The positive rate was compared among these groups. Results The positive rate of anti-titin antibody was significantly higher in MG with thymoma patients than MG patients(94% and 3%, P < 0.01). According to the Osserman′s classification, anti-titin antibody was present mostly in patients(43%)in Ⅳ stage, and also present in 2 cases of 7 who with no-MG thymoma. Conclusion Serum anti-titin antibody test is helpful in the diagnosis of MG with thymoma.