以更昔洛韦为主综合治疗婴幼儿毛细支气管炎

Compound Treatment of Bronchiolits in Infants Based on Ganciclovir

目的 为了探讨以静脉注射更昔洛韦为主综合治疗婴幼儿毛细支气管炎的临床疗效。方法 将78例毛细支气管炎患儿随机分为两组,观察组给予更昔洛韦治疗,对照组给予病毒唑治疗,并均佐以镇静、吸氧、超雾、止咳化痰、激素治疗、预防应用抗茵素等,对照两组方法治疗毛细支气管炎前后症状体征平均持续时间,疗效及观察治疗前后实验室指标如血常规及C-反应蛋白,胸部X线检查,支原体抗体测定及衣原体抗原测定,病毒血清学检测结果。结果 观察组气促缓解时间,肺部罗音、哮鸣音咳嗽消失时间,住院日及疗效与对照组比较均有显著差异性(P<0.01)。结论 更昔洛韦对于抗病毒疗效显著,作用迅速,抗病毒谱广,临床应用的安全性也相对较好,短期应用无明显的骨髓抑制作用。每日更昔洛韦(10 mg/kg)有较好的病毒抑制作用,为今后治疗病毒感染的研究提供了广阔的前景,值得推广应用。

Objective To demonstrate the compound clinical treatments of bronchiolitis mainly by Ganciclovir through the injection of vein. Methods Seventy-eight children with bronchiolitis are divided into two groups at random. The treatment of Ganciclovir was used in the observation group but Virazole was used in the control group. Both groups are as-sistant to aids by sedation, oxygen sucking,ultrasound misting,sputa reducing and cough reliefing,hydrocortisone,preventive anti-biotic and so on. Observation is particularly made to the lasting duration of symptoms and signs,effects,lab index-es such as routine blood and C-RP, X-ray examination, the tests of mycoplasma antibody, Chlamydia antigen and virus serology in each group. Results It shows that obvious differences can be found in the two groups concerning the duration of sputa easing,rales and wheeze sounds' disappearance,inpatient,also effects(ρ<0.01).Conclusion Ganciclovir has an obvious and rapid effect on anti-virus and it is rektively safe for clinical treatment. In the short term it has no obvious bone marrow suppression. Moreover, Ganciclovir,10 mg/(kg·d) ,has favorable effects on virus inhabitation and offers a bright prospect for the research of virus infection treatment in the near future, so it is well worth clinical applying.