肝硬化患者血浆抗坏血酸和维生素E的测定

Plasma levels of ascorbic acid and vitamin E in patients with liver cirrhosis

目的 :探讨肝硬化患者血浆抗坏血酸和维生素 E的水平及其意义。方法 :测定 6 3例肝硬化患者和 6 3例年龄及性别配对的正常人血浆抗坏血酸 ,维生素 E和过氧化脂质的含量。结果 :肝硬化组血浆抗坏血酸含量为( 42 .94± 6 .99)μm ol/ L ,明显低于对照组 ( 53.30± 9.4 5)μm ol/ L ( t=9.50 ,P =0 .0 0 0 ) ;肝硬化组血浆维生素 E含量为 ( 17.99± 3.51) μm ol/ L,明显低于对照组 ( 2 4 .59± 7.2 2 ) μm ol/ L( t=7.94 ,P=0 .0 0 0 ) ;肝硬化组血浆过氧化脂质含量为 ( 14 .0 9± 1.2 8) μm ol/ L,明显高于对照组 ( 12 .11± 1.2 0 ) μmol/ L( t=17.2 1,P=0 .0 0 0 )。而且肝硬化患者的三个指标之间均有良好的相关性 ( P=0 .0 0 0 )。结论 :肝硬化患者血浆抗坏血酸和维生素 E水平显著下降 ,体内氧化和抗氧化系统失衡。

Objective: To investigate the plasma levels of ascorbic acid and vitamin E in patients with liver cirrhosis and to explore their significance. Methods: The plasma levels of ascorbic acid,vitamin E and lipoperoxides in patients with liver cirrhosis were measured,and the results were compared with those of sex- and age-matched healthy subjects. Results: The plasma levels of ascorbic acid,vitamin E and lipoperoxides in the patients group were (42.94±6.99)μmol/L,(17.99±3.51)μmol/L and (14.09±1.28)μmol/L,respectively,while those in the control group were (53.30±9.45)μmol/L (t=9.50,P=0.000),(24.59±7.22)μmol/L (t=7.94,P=0.000) and (12.11±1.20)μmol/L (t=17.21,P=0.000),respectively. Conclusion: The levels of ascorbic acid and vitamin E in patients with liver cirrhosis decrease significantly,which may indicates the disturbance of balance between oxidation and antioxidation.