NMR Structural Studies on Alamethicin Dimers

NMR Structural Studies on Alamethicin Dimers

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摘要 N labeled alamethicin dimer was synthesized. The structure and dynamics of alamethicin dimers were studied with nuclear magnetic resonance (NMR) spectroscopy. The data from 15 N-labeled alamethicin dimer suggest little differences in conformation between the dimer and monomer in the Aib 1 -Pro 14 region. Significant difference in the conformation of the C-terminus are manifest in the NH chemical shifts in the Val 15 -Pho 20 region. N labeled alamethicin dimer was synthesized. The structure and dynamics of alamethicin dimers were studied with nuclear magnetic resonance (NMR) spectroscopy. The data from 15 N-labeled alamethicin dimer suggest little differences in conformation between the dimer and monomer in the Aib 1 -Pro 14 region. Significant difference in the conformation of the C-terminus are manifest in the NH chemical shifts in the Val 15 -Pho 20 region.

作者李星

机构地区 Environmental Engineering Department

出处《Journal of Southwest Jiaotong University(English Edition)》 2003年第2期172-181,共10页 西南交通大学学报（英文版）

基金 SurpportedbyCanadaNSERC (NationalScienceResearchCouncil)

关键词 ALAMETHICIN DIMER nuclear magnetic resonance spectroscopy alamethicin, dimer, nuclear magnetic resonance spectroscopy

分类号 O433 [机械工程—光学工程]

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Journal of Southwest Jiaotong University(English Edition)

2003年第2期

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NMR Structural Studies on Alamethicin Dimers

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