三七总皂甙在大鼠肝脏缺血再灌注损伤中肝细胞超微结构的保护作用

The Protective Role of Total Saponins of Panax Notognseng to the Super-microstructure in Rat Hepatocyte during Ischemia Reperfusion Injury

目的:观察三七总皂甙对大鼠肝脏缺血再灌注损伤的保护作用。方法:通过阻断血运前将PNS经直接通道注入并保留于肝脏组织的方法.电镜下观察肝细胞超微结构的病理变化过程。结果:电镜观察表明PNS组超微结构的破坏较对照组轻。结论:PNS具有减轻和预防大鼠缺血再灌注肝细胞核、线粒体等超微结构损伤的作用。

Objective:To observe the protective role of total saponins of panax notognseng to rat hepatocyte during ischemia reperfusion injury. Methods:PNS was directly injected into liver tissue and was kept there by blocking pro-tal vein and hepatic artery, and the pathologic changes of the hepatocyte super-micro structure was observed by electron microscope. Results:The pathologic changes of super-microstructure in the experimental group were less than thost in the control group. Conclusion: PNS had the function of relieving and preventing rat liver super-microstructure such as nucleus and mitochondrion from ischemia reperfusion injury.