肺癌手术期间血清IL-10含量及临床意义

Level and clinical significance of the serum IL-10 in perioperation of lung cancer

目的测定肺癌患者手术期间血清白细胞介素-10(interleukin-10,IL-10)含量,探讨肺癌手术期间血清IL-10含量的变化及临床意义。方法用放射免疫吸附法测定了39例肺癌患者手术期间及16例肺良性肿瘤患者和30例正常人血清IL-10含量并进行对照比较。结果肺癌组术前IL-10含量明显高于肺良性肿瘤组及正常人组(P<0.01),根治切除的肺癌患者血清IL-10含量术后明显下降,与术前相比,有非常显著性差异(P<0.01);开胸探查的肺癌患者术后24h轻度升高,72h恢复到术前含量。结论动态观察血清IL-10含量对肺癌诊断、判断手术效果、预测病情、指导术后治疗有重要的临床意义。

Objective To study the clinical significance of IL-10 in lung cancer by detecting serum IL-10 of patients with lung cancer. Methods Serum IL-10 levels were measured by radioimmunosorbent technique in 39 patients with lung cancer before surgery and after curative surgical resection, and 16 patients with lung benign tumor and 30 healthy volunteers then were compared. Results The serum IL-10 levels of patients with lung cancer were significantly higher than those of the other groups(P<0.01). Serum IL-10 levels of patients with lung cancer after curative surgical resection of tumors decreased significantly comparing with those before surgery (P<0.01). Serum levels of IL-10 in patients with lung cancer after palliative surgical resection of tumors did not decrease.Conclusion Dynamic detecting serum IL-10 levels may be helpful to the diagnosis and prediction of lung cancer.