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帕罗西汀对抑郁症患者血清甲状腺激素水平的影响 被引量:3

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摘要 目的 探讨帕罗西汀对抑郁症患者血清甲状腺激素水平的影响。方法 采用酶联免疫吸附法测定60例单一选用帕罗西汀治疗的抑郁症患者治疗前及治疗4周末的血清游离甲状腺激素(FT3、FT4)和促甲状腺激素(TSH)水平。结果 帕罗西汀治疗后抑郁症患者血清FT4水平较治疗前降低(P<0.001),对帕罗西汀疗效较好的患者较疗效差者血清FT4降低尤为明显(P<0.05),血清FTd水平相对偏高的患者治疗后降低明显(P<0.01)。结论 帕罗西汀治疗可引起抑郁症患者血清FT4水平降低,且在疗效较好的及血清FT4水平偏高的患者中降低明显。
出处 《中国神经精神疾病杂志》 CAS CSCD 北大核心 2003年第6期460-461,共2页 Chinese Journal of Nervous and Mental Diseases
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同被引文献39

  • 1陈佐明,张迎黎,李占文,梁炜,张朝辉,张红梅,张建宏.抑郁症的认知研究[J].上海精神医学,2004,16(6):334-335. 被引量:21
  • 2方泽忠,胡健波,许毅.抑郁症患者治疗前后甲状腺激素水平分析[J].浙江医学,2005,27(12):888-890. 被引量:8
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  • 6Koning F, Hauger HC. Effect of paroxetine on thyroid hormone levels in severely depressed patients[J]. Neuropsychobiology, 2000,42(3) : 135.
  • 7Shelton RC,Winns, Ekhatore N. The effect of antidepressants on the thyroid axis in depression[J]. Bio Psychiatry, 1993,33 (2):120.
  • 8Moreau X,Azorin JM, Lejeune PJ,et al. Red blood cell triothyronine uptake in unipolar major depression:effect of a chronic antidepressant treatment [J]. Prog Neuropsycho - pharmacoi Biol Psychiatry, 2000,4 ( 1 ) : 23.
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