以神经系统表现为主的莱姆病17例临床分析

Clinical Analysis of 17 Cases with Lyme Disease Displaying mainly Neurological Manifestations

目的分析莱姆病的神经系统表现及其诊断和治疗。方法对 17例莱姆病患者的神经系统表现及辅助检查结果进行回顾性分析。结果莱姆病的神经系统表现复杂 ,以中枢神经和周围神经损害的表现为主。血和脑脊液伯氏疏螺旋体抗体滴度为 1∶6 4～ 1∶5 0 0。结论莱姆病的神经系统表现无特异性 ,早期诊断难 ,根据临床表现、流行病学资料和抗体检查可协助诊断 ,治疗以抗生素为主。

ObjectivesTo analyze the neurological manifestations of Lyme disease (LD) as well as its diagnosis and treatment.MethodsThe neurological manifestations and results of auxiliary examination in 17 LD patients were analyzed retrospectively.ResultsNeurological manifestations of LD were considerably complicated ; both central and peripheral nerve systems were mainly involved in these cases. An elevated antibody titer against Borrelia burgdorferi (1∶64～1∶500) was found in serum and cerebrospinal fluid (CSF).ConclusionIt is difficult to make early diagnosis of LD, for its neurological manifestations are usually non-specific. Clinical symptoms, epidemiological data and antibody detection can help the diagnosis ; while antibiotics are the chief measure of treatment.