纳洛酮对小儿流行性乙型脑炎治疗的临床研究

A clinical study on the therapy of naloxne for children with epidemic type B encephalitis

目的:探讨纳洛酮对小儿流行性乙型脑炎的临床疗效.方法:治疗组在对照组综合治疗基础上加用纳洛酮0.01 mg/(kg·次)静滴,每6 h一次(4次/d),疗程3～5 d,观察两组的临床疗效.结果:治疗组住院时间、退热、抽搐停止、神志转清及脑膜刺激征消失时间均较对照组明显缩短(P＜0.05或0.01);治疗组治愈率明显高于对照组(P＜0.05).结论:纳洛酮治疗乙脑可显著提高治愈率,改善预后.

Objective: To explore the clinical effect of naloxne on children with epidemic type B encephalitis. Methods: Naloxne (0.01mg/kg q6h, the duration was 3~5 days) was administrated in the treated group intravenously besides the regular treatment. The clinical manifestations were analyzed and compared with the control group. Results: The hospital-treated duration and the recovery time of fever, seizures, sensory changes, meningeal irritation were more shortened in the treated group compared with the control group significantly ( P < 0.05 or 0.01). The cure rate in the treated group was significantly higher than that in the control group ( P < 0.05). Conclusion: The cure rate was increased obviously by using naloxne in children with epidemic type B encephalitis. The therapy with naloxne on epidemic type B encephalitis can improve its prognosis.