Ε-cadherin和β-catenin在大肠癌组织中的表达及与预后的关系

Expression of E-cadherin and β-catenin in colorectal carcinoma and relationship with prognosis.

目的 探讨E-cd及β-cat的表达与大肠癌临床病理因素和预后的关系。方法 采用免疫组化S-P法,检测139例大肠癌组织标本中E-cd及β-cat的表达。结果 研究显示E-cd异常表达率与大肠癌分化程度呈负相关,与淋巴结转移及Dukes分期呈正相关。而β-cat异常表达率只与大肠癌分化程度呈负相关。且E-cd及β-cat异常表达均与不良预后相关。结论 E-cd及β-cat的异常表达与刁肠癌的侵袭、转移及预后相关。

Objective To elucidate weather the expression of E-cadherin and β-catenin correlates with clinicopathological variables and prognosis of colorectal carcinoma. Methods We performed E-cadherin and β-catenin expression investigation with immunohistochemical method on 139 colorectal cancers. Results Significant inverse correlation existed between the abnormal expression of E-cadherin and β-catenin and histologic grade. And abnormal expression of E-cadherin also correkted significantly with lymph node metastases, and clinical staging. Both abnormal expression of E-cadherin and β-catenin correlated with poor survival. Conclusion Abnomal expression of E-cadherin and β-catenin correlated with invasion, matestasis and prognosis of colorectal carcinoma.