儿科各种退热疗法临床效果比较

Efficacy of ibuprofen on the treatment of febrile children

目的:探讨不同退热药物的退热效果,总结各种措施的副作用及儿科医生首选用药。方法:对210例病毒性呼吸道感染所致861例次高热(>39℃)患儿,分别予不同的退热药物及各自联合物理降温治疗,观察用药1h后的退热效果。结果:安乃近、复方阿斯匹林、对乙酰氨基酚糖浆与布洛芬混悬液退热总有效率分别为78%、76%、81%与89%(χ2为6.81、8.64、3.97,P<0.05)。布洛芬混悬液退热效果显著优于安乃近、复方阿斯匹林、对乙酰氨基酚糖浆,且不良反应最少,联合物理降温有协同效应。结论:布洛芬混悬液退热效果肯定,不良反应少,值得临床应用。

Objective: To evaluate the febricide efficacy of ibuprofen suspension and use antipyretic reasonably. Methods: The 861 high febrility (>39℃) of 210 in-patients and out-patients with acute viral respiratory tract infection were treated with analginum, aspirin, paracetamol oral solution and ibuprofen suspension respectively. The body temperature and the obvious side effects were recorded 1 hour after these drugs were used and the first drug that pediatrician selected was also recorded. Results: The effective rate of analginum, aspirin, paracetamol oral solution and ibuprofen suspension were 78%, 76%, 81% and 89% ( χ2=6.81, 8.64, 3.97, P < 0.05) respectively. The difference was significant. The side effects of ibuprofen suspension were less than others. But the first drug was analginum. Conclusion: Ibuprofen suspension is more efficacy and safe obviously than other antipyretics for treating children's febricity.