P^(27kipl)、cyclinE与结肠癌临床病理因素及预后关系的研究

The study of relationship between expression of p27kip1、cyclinE and clini-copathological parameters as well as prognosis of colon cancer

目的 分析p^(27kipl)、cyclinE与结肠癌生物学行为和预后的关系。方法 采用S-P法免疫组化观察71例结肠癌与21例正常肠粘膜组织的P^(27kipl)和cyclinE的表达情况。结果 p^(27kipl)、cyclinE异常表达同结肠癌的发生与进展有关。结论P^(27kipl)、cyclinE联合检测有利于对结肠癌预后的评价。

To analyze the relationship between the biological behaviour and prognosis of colon cancer and P27kipl and cyclinE. Methods The expression of P27kipl and cyclinE in the species, which came from 71 cases of colon cancers and 21 cases of normal colon, were observed by SP immunohistochemical method. Results Abnormal expression of P27kipl and cyclinE was related to the occurrence and colon cancer. Conclusion Detecting the expression of P27kipl and cyclinE benefits the evaluation of the recurrence status in colon cancer.