粘膜相关淋巴组织淋巴瘤的临床研究

Clinical Pathologic Study and Therapy of Mucosa-associated Lymphoid Tissue Lymphoma

目的 提高对黏膜相关淋巴组织 (MALT)淋巴瘤临床特征的认识。方法 经我院确诊的MALT淋巴瘤 12例 ,进行回顾性临床分析研究。结果 按原发部位可分为胃肠 (GI)和非胃肠 (NON GI)两组。GI组 6例 ( 5 0 % ) ,NON GI组 6例 ( 5 0 % ) ,后者包括膀胱 2例 ,睾丸 1例 ,甲状腺 1例 ,乳腺 1例 ,眼眶 1例。手术治疗 11例 ,其中单用手术治疗 4例 ,手术加化疗 7例。单用化疗 1例。随访 12例 ,1例死亡 ,11例存活 1年 ,6例存活 3年 ,2例存活 5年。结论 MALT淋巴瘤是非霍奇金淋巴瘤的一种独特亚型 ,具有起病隐匿、病程长、进展慢及患病率低 ,好发于中老年男性 ,B组症状少见 ,治疗效果和预后良好等特征。

Objective To have a better understanding of the clinical characteristics of mucosa-associated lymphoid tissue(MALT) lymphoma.Methods The clinical data of 12 patients with MALT lymphoma were analyzed.Results The patients were divided into two groups according to the initial location of the lymphoma in the gastrointestinal (GI) tract or not. Six patients(50%) had GI involvement and six (50%) had involvement of other extra nodal sites including bladder in two,testicle in one,thyroid in one, mammary gland in one, orbit in one. Among the 12 cases,surgical resection was performed alone in 11, with adjuvant chemotherapy in 7,one patient was treated with chemotherapy only. The results of survival analysis showed that the overall survival rate was 91.7% after 1 year,50% after 3 years,16.7% after 5 years.Conclusions MALT lymphoma is a special disease that presents in localized extra nodal location without any associated adverse prognostic factor in all the nearly patients and these patients have a high response rate to treatment and a long survival.