痴呆及其心理、行为症状与血浆同型半胱氨酸水平关系

The Relationship of dementia and psychological and behavioral symptoms of dementia to plasma homocysteine

目的 探讨痴呆及痴呆心理和行为症状 (Psychologicalandbehavioralsymptomsofdementia ,BPSD)的可能发病机制 ,研究血浆同型半胱氨酸 (homocysteine ,Hcy)水平与痴呆及BPSD的关系。 方法 阿尔茨海默病(AlzheimerDisease ,AD)、混合性痴呆 (Mixeddementia ,MD)、血管性痴呆 (Vasculardementia ,VD)和正常对照组各 3 0例参加本研究。采用Alzheimer病行为症状评定量表 (TheBehavioralPathlologyinAlzheimerDiseaseRatingScale ,BEHAVE AD)评定痴呆患者BPSD。采用高压毛细血管电泳紫外检测法测定经 2 ,4 二硝基氟苯 (2 ,4 dimntrifluorobenzen ,DNFB)衍生后的血浆Hcy水平。 结果 AD、MD和VD患者血浆Hcy浓度均显著高于正常对照组 ,血浆高Hcy水平的痴呆患者BEHAVE AD总分较高。 结论 血浆高Hcy水平不仅与痴呆的发生发展有关 。

Objective To investigate the relationship between plasma homocystetine (Hcy) level to dementia and Psychological and behavioral symptoms of dementia (BPSD). Methods The study involved 90 patients with dementia (30 patients with AD, 30 patients with MD, 30 patients with VD) and 30 healthy controls. BPSD were assessed by the Behavioral Pathology in Alzheimer's Disease Rating Scale (BEHAVE AD). The plasma Hcy levels derivatized by the 2, 4 dimntrofluorobenzen (DNFB) was measured using high voltage capillary electrophoresis (CE) with ultraviolet (UV) detection. Results The plasma Hcy in patients with dementia was significantly higher than that in the controls. The total score of BEHAVE AD in the patients with high plasma Hcy was significantly higher than that in the patients with normal plasma Hcy. Conclusions The elevated plasma Hcy level is involved in the pathogenesis of dementia and BPSD.