SIRS患者血小板4项参数变化及临床意义

The Change Trend and Clinical Significance of Four Parameters of Blood Platelet in the Progress of SIRS

目的:观察血小板4项参数(BPC血小板计数、MPV血小板平均体积、PCT血小板比积、PDW血小板分布宽度)在SIRS(全身炎症反应综合征)发展过程中的变化趋势及其临床意义.方法:对正常对照组、SIRS组(未达MODS)和MODS(多器官功能障碍综合征)组进行PLT、MPV、PCT、PDW记录与统计分析;同时也记录S组(由非SIRS发展到SIRS的病人但未达到MODS者)、M组(由SIRS发展到MODS者)的病人4项参数变化,进行自身对照,统计分析.结果:对照组BPC(×109/L)为200.72±52.09,MPV(fl)为10.03±1.83,PCT(%)为0.1991±0.0564,PDW(%SD)为17.59±0.94;SIRS组分别为121.94±44.46、10.98±2.34、0.1263±0.0396、17.57±1.64;MODS组分别为51.74±24.55、10.75±2.54、0.0674±0.0454、18.77±2.45;其中BPC和PCT三组对比均有显著性差异(P＜0.05).SIRS组和对照组MPV比较有显著性差异(P＜0.05).MODS组和对照组、SIRS组的PDW比较均有显著性差异(P＜0.05).S组4项参数前后差值为-125.55±60.66(P＜0.001)、1.116±1.944(P=0.000)、-0.0953 ±0.0696(P＜0.000)、0.2370±1.3767(P=0.249);M组4项参数前后差值为-67.54±42.23(P＜0.000)、0.7629±1.9071(P＜0.05)、-0.0453±-0.0392(P＜0.001)、1.886±1.912(P＜0.001).结论:在SIRS发展过程中,PLT、PCT进行性下降,MPV、PDW逐渐上升,SIRS病人上述变化趋势提示病情加重.

Purpose: To observe the change trend and clinical significance of four parameters of blood platelet ( BPC platelet count, MPV mean platelet volume,PCT platelet crit,PDW platelet distribution width) in the progress of SIRS(systemic inflammatory response syndrome) . Methods: Record BPC , MPV , PCT, PDW of control group, SIRS group (not reaching MODS) and MODS group and statistically analyse; meanwhile,recorded S group(SIRS patients developing from non-SIRS and not reaching MODS) and M group( MODS patients developing from SIRS) ,then do it as well. Results: BPC( ×109/L ,MPV(ft) ,PCT(% ) ,PDW(%SD) of control group is 200.72±52.09,10.03±1.83,0. 1991±0.0564,17. 59±0.94 respectively;in SIRS group was 121. 94±44.46,10.98±2. 34,0. 1263±0. 0396,17. 57±1. 64;in MODS group was 51. 74±24. 55 .10. 75±2. 54,0. 0674±0. 0454 ,18. 77±2. 45 ; among them, the difference of BPC and PCT between three groups were all significant ( P <0. 05) ,the difference of MPV between SIRS group and control group was significant! P < 0. 05) , the difference of PDW between MODS group and either of control group and SIRS group was significant ( P <0. 05 ) ;the before and the after difference of four parameters of S group was - 125. 55±60. 66( P < 0. 001 ) , 1. 116±1. 944 ( P< 0. 001 ) , - 0. 0953±0. 0696 ( P < 0. 001 ) , 0. 2370±1. 3767 ( P =0. 249) ;the before and the after difference of four parameters of M group is -67. 54±42. 23 ( P <0. 001) ,0. 7629±1.9071( P <0. 05) , -0.0453±-0. 0392( P <0. 001) , 1. 886±1. 912( P <0.001). Conclusion: In the progress of SIRS, BPC and PCT are getting lower and lower,MPV and PDW are getting higher and higher,the above chang of SIRS patients indicate aggravation.