牛磺胆酸钠的合成

Synthesis of Sodium Taurocholate

以喹啉为起始原料 ,先后与氯甲酸乙酯、乙醇反应制得 N-乙氧羰基 - 2 -乙氧基 - 1,2 -二氢喹啉 (收率 2 5 % ) ,以此为肽键偶联剂 ,用胆酸与牛磺酸缩合制得牛磺胆酸钠 ,收率 92 .5 %。

N Ethoxycarbonyl 2 ethoxy 1,2 dihydroqinoline was synthesized from quinoline in 25% yield and used as a reagent for the condensation of bile acid and taurine in DMF in the presence of tri ethylamine in 92.5% yield.